Neurofeedback-linked suppression of cortical β bursts speeds up movement initiation in healthy motor control: a double-blind sham-controlled study

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He, S, Everest-Phillips, C, Clouter, A ORCID: https://orcid.org/0000-0002-3039-4018, Brown, P and Tan, H, 2020. Neurofeedback-linked suppression of cortical β bursts speeds up movement initiation in healthy motor control: a double-blind sham-controlled study. The Journal of Neuroscience, 40 (20), pp. 4021-4032. ISSN 1529-2401

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Official URL: https://doi.org/10.1523/jneurosci.0208-20.2020

Abstract

Abnormally increased β bursts in cortical-basal ganglia-thalamic circuits are associated with rigidity and bradykinesia in patients with Parkinson's disease. Increased β bursts detected in the motor cortex have also been associated with longer reaction times (RTs) in healthy participants. Here we further hypothesize that suppressing β bursts through neurofeedback training can improve motor performance in healthy subjects. We conducted a double-blind sham-controlled study on 20 human volunteers (10 females) using a sequential neurofeedback-behavior task with the neurofeedback reflecting the occurrence of β bursts over sensorimotor cortex quantified in real time. The results show that neurofeedback training helps healthy participants learn to volitionally suppress β bursts in the sensorimotor cortex, with training being accompanied by reduced RT in subsequent cued movements. These changes were only significant in the real feedback group but not in the sham group, confirming the effect of neurofeedback training over simple motor imagery. In addition, RTs correlated with the rate and accumulated duration of β bursts in the contralateral motor cortex before the go-cue, but not with averaged β power. The reduced RTs induced by neurofeedback training positively correlated with reduced β bursts across all tested hemispheres. These results strengthen the link between the occurrence of β bursts in the sensorimotor cortex before the go-cue and slowed movement initiation in healthy motor control. The results also highlight the potential benefit of neurofeedback training in facilitating voluntary suppression of β bursts to speed up movement initiation.

Item Type:	Journal article
Publication Title:	The Journal of Neuroscience
Creators:	He, S., Everest-Phillips, C., Clouter, A., Brown, P. and Tan, H.
Publisher:	Society for Neuroscience
Date:	13 May 2020
Volume:	40
Number:	20
ISSN:	1529-2401
Identifiers:	Number Type 10.1523/jneurosci.0208-20.2020 DOI 1728202 Other
Rights:	© 2020 He et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
Divisions:	Schools > School of Social Sciences
Record created by:	Jeremy Silvester
Date Added:	10 Feb 2023 16:49
Last Modified:	10 Feb 2023 16:49
URI:	https://irep.ntu.ac.uk/id/eprint/48253