Combinational system of lipid-based nanocarriers and biodegradable polymers for wound healing: an updated review

Farasati Far, B, Naimi-Jamal, MR, Sedaghat, M, Hoseini, A, Mohammadi, N and Bodaghi, M ORCID: https://orcid.org/0000-0002-0707-944X, 2023. Combinational system of lipid-based nanocarriers and biodegradable polymers for wound healing: an updated review. Journal of Functional Biomaterials, 14 (2): 115. ISSN 2079-4983

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Abstract

Skin wounds have imposed serious socioeconomic burdens on healthcare providers and patients. There are just more than 25,000 burn injury-related deaths reported each year. Conventional treatments do not often allow the re-establishment of the function of affected regions and structures, resulting in dehydration and wound infections. Many nanocarriers, such as lipid-based systems or biobased and biodegradable polymers and their associated platforms, are favorable in wound healing due to their ability to promote cell adhesion and migration, thus improving wound healing and reducing scarring. Hence, many researchers have focused on developing new wound dressings based on such compounds with desirable effects. However, when applied in wound healing, some problems occur, such as the high cost of public health, novel treatments emphasizing reduced healthcare costs, and increasing quality of treatment outcomes. The integrated hybrid systems of lipid-based nanocarriers (LNCs) and polymer-based systems can be promising as the solution for the above problems in the wound healing process. Furthermore, novel drug delivery systems showed more effective release of therapeutic agents, suitable mimicking of the physiological environment, and improvement in the function of the single system. This review highlights recent advances in lipid-based systems and the role of lipid-based carriers and biodegradable polymers in wound healing.

Item Type:	Journal article
Publication Title:	Journal of Functional Biomaterials
Creators:	Farasati Far, B., Naimi-Jamal, M.R., Sedaghat, M., Hoseini, A., Mohammadi, N. and Bodaghi, M.
Publisher:	MDPI
Date:	18 February 2023
Volume:	14
Number:	2
ISSN:	2079-4983
Identifiers:	Number Type 10.3390/jfb14020115 DOI 1751453 Other
Rights:	© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Divisions:	Schools > School of Science and Technology
Record created by:	Jonathan Gallacher
Date Added:	18 Apr 2023 14:03
Last Modified:	18 Apr 2023 14:03
URI:	https://irep.ntu.ac.uk/id/eprint/48772

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