Regulation of autophagy by plant‐based polyphenols: a critical review of current advances in glucolipid metabolic diseases and food industry applications

Wang, Z, Quan, W, Zeng, M, Wang, Z, Chen, Q, Chen, J, Christian, M ORCID: https://orcid.org/0000-0002-1616-4179 and He, Z, 2023. Regulation of autophagy by plant‐based polyphenols: a critical review of current advances in glucolipid metabolic diseases and food industry applications. Food Frontiers. ISSN 2643-8429

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Abstract

Autophagy is a complex self-degrading process, and its imbalance adversely affects local (metabolically active organs) or systemic metabolism, resulting in metabolic dysfunction correlated with obesity, fatty liver, and type 2 diabetes. Polyphenols are plant secondary metabolites and their ingestion may offer beneficial effects on biological processes, including cell proliferation, cell cycle, apoptosis and autophagy. In this review, the effects of plant-based polyphenols on autophagy and the underlying mechanisms in the regulation of glucolipid metabolic diseases (GLMDs) are examined in the context of potential health benefits. The available evidence, mainly from animal models, strongly supports that polyphenols improve the metabolic functions of different organs by acting on various molecular targets related to autophagic flux. Multiple autophagic pathways, including cAMP, AMPK, MAPK, AKT, SIRT1, PI3K, Nrf2/HO-1, PINK1/Parkin, PPARδ, and miRNAs have been implicated in the improvement of GLMDs by polyphenols. Moreover, the potential utilization of polyphenol-meditated autophagy in the food industry was discussed. The current review provides a comprehensive understanding of the prospective role and mechanisms of polyphenol-regulated autophagy in GLMDs and opens up future insights into its application to the healthcare and food industries.

Item Type:	Journal article
Publication Title:	Food Frontiers
Creators:	Wang, Z., Quan, W., Zeng, M., Wang, Z., Chen, Q., Chen, J., Christian, M. and He, Z.
Publisher:	Wiley
Date:	23 May 2023
ISSN:	2643-8429
Identifiers:	Number Type 10.1002/fft2.255 DOI 1765503 Other
Rights:	© 2023 The Authors. Food Frontiers published by John Wiley & Sons Australia, Ltd and Nanchang University, Northwest University, Jiangsu University, Zhejiang University, Fujian Agriculture and Forestry University. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Divisions:	Schools > School of Science and Technology
Record created by:	Laura Ward
Date Added:	26 May 2023 09:18
Last Modified:	26 May 2023 09:18
URI:	https://irep.ntu.ac.uk/id/eprint/49080

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