Vaterite-nanosilver hybrids with antibacterial properties and pH-triggered release

Ferreira, AM, Vikulina, A, Cave, GWV ORCID logoORCID: https://orcid.org/0000-0002-4167-1332, Loughlin, M, Puddu, V ORCID logoORCID: https://orcid.org/0000-0001-5079-5508 and Volodkin, D ORCID logoORCID: https://orcid.org/0000-0001-7474-5329, 2023. Vaterite-nanosilver hybrids with antibacterial properties and pH-triggered release. Materials Today Chemistry, 30: 101586. ISSN 2468-5194

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Abstract

Silver nanoparticles (AgNPs) have been used for over a century in various applications due to their distinctive properties. Nonetheless, the poor stability of AgNPs and adverse effects on living organisms have driven the search for materials able to protect and better control their release. Vaterite CaCO3 crystals have been studied in the last two decades as carriers for different drugs due to their biocompatibility, easy synthesis and pH-sensitive properties. Herein, AgNPs were loaded into vaterite to protect, store, and control their release, resulting in CaCO3/AgNPs hybrids. To tune the release of the AgNPs, the recrystallization of the hybrids into thermodynamically more stable calcite was studied and modulated with carboxymethyledextran (DexCM) and poly(4-styrenesulfonic acid) sodium salt (PSS), with the last one being able to stabilise the hybrids and prevent a premature release of the AgNPs at low contents (2%, w/w). The release of AgNPs from the hybrids was studied at pH 5 to 9, showing a pH-dependent release suppression for PSS-stabilised hybrids. Various mathematical models were applied to clarify the release mechanism, confirming the role of PSS in stabilising and targeting the release of AgNPs. The antibacterial studies demonstrated that the hybrids protect the AgNPs without affecting their activity, with the released nanoparticles being effective against Escherichia coli, methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa. Overall, this work sheds light on the release mechanisms of AgNPs from the inorganic hybrids helping to foresee the release profiles of other compounds from vaterite.

Item Type: Journal article
Publication Title: Materials Today Chemistry
Creators: Ferreira, A.M., Vikulina, A., Cave, G.W.V., Loughlin, M., Puddu, V. and Volodkin, D.
Contributors:
Name
Role
NTU ID
ORCID
HICKMAN, G.J.
Collector
UNSPECIFIED
Publisher: Elsevier
Date: June 2023
Volume: 30
ISSN: 2468-5194
Identifiers:
Number
Type
10.1016/j.mtchem.2023.101586
DOI
S2468519423002136
Publisher Item Identifier
1769325
Other
Rights: © 2023 the author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Divisions: Schools > School of Science and Technology
Record created by: Jonathan Gallacher
Date Added: 13 Jun 2023 15:11
Last Modified: 13 Jun 2023 15:27
URI: https://irep.ntu.ac.uk/id/eprint/49197

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