Advances in genetics and epigenetics of developmental coordination disorder in children

You, H, Shi, J, Huang, F, Wei, Z, Jones, G ORCID: https://orcid.org/0000-0003-3867-9947, Du, W ORCID: https://orcid.org/0000-0002-5115-7214 and Hua, J, 2023. Advances in genetics and epigenetics of developmental coordination disorder in children. Brain Sciences, 13 (6): 940. ISSN 2076-3425

Preview

Text 1770807_Jones.pdf - Published version Download (537kB) | Preview

Abstract

Developmental coordination disorder (DCD) is a developmental disorder characterized by impaired motor coordination, often co-occurring with attention deficit disorder, autism spectrum disorders, and other psychological and behavioural conditions. The aetiology of DCD is believed to involve brain changes and environmental factors, with genetics also playing a role in its pathogenesis. Recent research has identified several candidate genes and genetic factors associated with motor impairment, including deletions, copy number variations, single nucleotide polymorphisms, and epigenetic modifications. This review provides an overview of the current knowledge in genetic research on DCD, highlighting the importance of continued research into the underlying genetic mechanisms. While evidence suggests a genetic contribution to DCD, the evidence is still in its early stages, and much of the current evidence is based on studies of co-occurring conditions. Further research to better understand the genetic basis of DCD could have important implications for diagnosis, treatment, and our understanding of the condition's aetiology.

Item Type:	Journal article
Publication Title:	Brain Sciences
Creators:	You, H., Shi, J., Huang, F., Wei, Z., Jones, G., Du, W. and Hua, J.
Publisher:	MDPI
Date:	11 June 2023
Volume:	13
Number:	6
ISSN:	2076-3425
Identifiers:	Number Type 10.3390/brainsci13060940 DOI 1770807 Other
Divisions:	Schools > School of Social Sciences
Record created by:	Jonathan Gallacher
Date Added:	19 Jun 2023 08:30
Last Modified:	19 Jun 2023 08:30
URI:	https://irep.ntu.ac.uk/id/eprint/49212

Actions (login required)

Edit View

Statistics

Views

Downloads