Chronic exposure to dim light at night or irregular lighting conditions impact circadian behavior, motor coordination, and neuronal morphology

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Delorme, TC, Srikanta, SB, Fisk, AS, Cloutier, M-È, Sato, M, Pothecary, CA, Merz, C, Foster, RG, Brown, SA, Peirson, SN, Cermakian, N and Banks, GT ORCID: https://orcid.org/0000-0002-8647-667X, 2022. Chronic exposure to dim light at night or irregular lighting conditions impact circadian behavior, motor coordination, and neuronal morphology. Frontiers in Neuroscience, 16: 855154. ISSN 1662-4548

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Official URL: https://doi.org/10.3389/fnins.2022.855154

Abstract

Mistimed exposure to light has been demonstrated to negatively affect multiple aspects of physiology and behavior. Here we analyzed the effects of chronic exposure to abnormal lighting conditions in mice. We exposed mice for 1 year to either: a standard light/dark cycle, a “light-pollution” condition in which low levels of light were present in the dark phase of the circadian cycle (dim light at night, DLAN), or altered light cycles in which the length of the weekday and weekend light phase differed by 6 h (“social jetlag”). Mice exhibited several circadian activity phenotypes, as well as changes in motor function, associated particularly with the DLAN condition. Our data suggest that these phenotypes might be due to changes outside the core clock. Dendritic spine changes in other brain regions raise the possibility that these phenotypes are mediated by changes in neuronal coordination outside of the clock. Given the prevalence of artificial light exposure in the modern world, further work is required to establish whether these negative effects are observed in humans as well.

Item Type:	Journal article
Publication Title:	Frontiers in Neuroscience
Creators:	Delorme, T.C., Srikanta, S.B., Fisk, A.S., Cloutier, M.-È., Sato, M., Pothecary, C.A., Merz, C., Foster, R.G., Brown, S.A., Peirson, S.N., Cermakian, N. and Banks, G.T.
Publisher:	Frontiers Media SA
Date:	2022
Volume:	16
ISSN:	1662-4548
Identifiers:	Number Type 10.3389/fnins.2022.855154 DOI 1783713 Other
Rights:	Copyright © 2022 Delorme, Srikanta, Fisk, Cloutier, Sato, Pothecary, Merz, Foster, Brown, Peirson, Cermakian and Banks. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Divisions:	Schools > School of Science and Technology
Record created by:	Linda Sullivan
Date Added:	19 Jul 2023 10:15
Last Modified:	19 Jul 2023 10:15
URI:	https://irep.ntu.ac.uk/id/eprint/49386