Effects of porosity on drug release kinetics of swellable and erodible porous pharmaceutical solid dosage forms fabricated by hot melt droplet deposition 3D printing

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Zhang, B, Nasereddin, J, McDonagh, T, von Zeppelin, D, Gleadall, A, Alqahtani, F, Bibb, R ORCID: https://orcid.org/0000-0002-3975-389X, Belton, P and Qi, S, 2023. Effects of porosity on drug release kinetics of swellable and erodible porous pharmaceutical solid dosage forms fabricated by hot melt droplet deposition 3D printing. International Journal of Pharmaceutics, 604: 120626. ISSN 0378-5173

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Official URL: https://doi.org/10.1016/j.ijpharm.2021.120626

Abstract

3D printing has the unique ability to produce porous pharmaceutical solid dosage forms on-demand. Although using porosity to alter drug release kinetics has been proposed in the literature, the effects of porosity on the swellable and erodible porous solid dosage forms have not been explored. This study used a model formulation containing hypromellose acetate succinate (HPMCAS), polyethylene oxide (PEO) and paracetamol and a newly developed hot melt droplet deposition 3D printing method, Arburg plastic free-forming (APF), to examine the porosity effects on in vitro drug release. This is the first study reporting the use of APF on 3D printing porous pharmaceutical tablets. With the unique pellet feeding mechanism of APF, it is important to explore its potential applications in pharmaceutical additive manufacturing. The pores were created by altering the infill percentages (%) of the APF printing between 20 to 100% to generate porous tablets. The printing quality of these porous tablets were examined. The APF printed formulation swelled in pH 1.2 HCl and eroded in pH 6.8 PBS. During the dissolution at pH 1.2, the swelling of the printing pathway led to the gradual decreases in the open pore area and complete closure of pores for the tablets with high infills. In pH 6.8 buffer media, the direct correlation between drug release rate and infills was observed for the tablets printed with infill at and less than 60%. The results revealed that drug release kinetics were controlled by the complex interplay of the porosity and dynamic changes of the tablets caused by swelling and erosion. It also implied the potential impact of fluid hydrodynamics on the in vitro data collection and interpretation of porous solids.

Item Type:	Journal article
Publication Title:	International Journal of Pharmaceutics
Creators:	Zhang, B., Nasereddin, J., McDonagh, T., von Zeppelin, D., Gleadall, A., Alqahtani, F., Bibb, R., Belton, P. and Qi, S.
Publisher:	Elsevier BV
Date:	15 July 2023
Volume:	604
ISSN:	0378-5173
Identifiers:	Number Type 10.1016/j.ijpharm.2021.120626 DOI 1799568 Other
Divisions:	Schools > Nottingham School of Art & Design
Record created by:	Laura Ward
Date Added:	12 Sep 2023 15:18
Last Modified:	12 Sep 2023 15:18
URI:	https://irep.ntu.ac.uk/id/eprint/49688