Development of combi-pills using the coupling of semi-solid syringe extrusion 3D printing with fused deposition modelling

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Zhang, B, Teoh, XY, Yan, J, Gleadall, A, Belton, P, Bibb, R ORCID: https://orcid.org/0000-0002-3975-389X and Qi, S, 2022. Development of combi-pills using the coupling of semi-solid syringe extrusion 3D printing with fused deposition modelling. International Journal of Pharmaceutics, 625: 122140. ISSN 0378-5173

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Official URL: https://doi.org/10.1016/j.ijpharm.2022.122140

Abstract

Three-dimensional (3D) printing allows for the design and printing of more complex designs than traditional manufacturing processes. For the manufacture of personalised medicines, such an advantage could enable the production of personalised drug products on demand. In this study, two types of extrusion-based 3D printing techniques, semi-solid syringe extrusion 3D printing and fused deposition modelling, were used to fabricate a combi-layer construct (combi-pill). Two model drugs, tranexamic acid (water soluble, rapid release) and indomethacin (poorly water-soluble, extended release), were printed with different geometries and materials compositions. Fourier transform infrared spectroscopy results showed that there were no interactions detected between drug-drug and drug-polymers. The printed combi-pills demonstrated excellent abrasion resisting properties in friability tests. The use of different functional excipients demonstrated significant impact on in vitro drug release of the model drugs incorporated in two 3D printed layers. Tranexamic acid and indomethacin were successfully 3D printed as a combi-pill with immediate-release and sustained-release profiles, respectively, to target quick anti-bleeding and prolonged anti-inflammation functions. For the first time, this paper systematically demonstrates the feasibility of coupling syringe-based extrusion 3D printing and fused deposition modelling as an innovative platform for various drug therapy productions, facilitating a new era of personalised combi-pills development.

Item Type:	Journal article
Publication Title:	International Journal of Pharmaceutics
Creators:	Zhang, B., Teoh, X.Y., Yan, J., Gleadall, A., Belton, P., Bibb, R. and Qi, S.
Publisher:	Elsevier
Date:	September 2022
Volume:	625
ISSN:	0378-5173
Identifiers:	Number Type 10.1016/j.ijpharm.2022.122140 DOI S0378517322006937 Publisher Item Identifier 1805014 Other
Rights:	This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Divisions:	Schools > Nottingham School of Art & Design
Record created by:	Jonathan Gallacher
Date Added:	20 Sep 2023 09:49
Last Modified:	20 Sep 2023 09:49
URI:	https://irep.ntu.ac.uk/id/eprint/49760