Ultra-high-field 7T MRI reveals changes in human medial temporal lobe volume in female adults during menstrual cycle

Zsido, RG, Williams, AN ORCID: https://orcid.org/0000-0001-9363-8537, Barth, C, Serio, B, Kurth, L, Mildner, T, Trampel, R, Beyer, F, Witte, AV, Villringer, A and Sacher, J, 2023. Ultra-high-field 7T MRI reveals changes in human medial temporal lobe volume in female adults during menstrual cycle. Nature Mental Health, 1 (10), pp. 761-771. ISSN 2731-6076

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Abstract

Ovarian hormones have substantial effects on the brain, and early menopause has been associated with increased risk of accelerated brain aging and dementia later in life. However, the impact of ovarian hormone fluctuations on brain structure earlier in life is less understood. Here we show that ovarian hormone fluctuations shape structural brain plasticity during the reproductive years. We use longitudinal ultra-high field neuroimaging across the menstrual cycle to map the morphology of medial temporal lobe subregions in 27 participants. Controlling for water content and blood flow, our findings reveal positive associations between estradiol and parahippocampal cortex volume, progesterone and subiculum and perirhinal area 35 volumes, and an estradiol*progesterone interaction with CA1 volume. This research offers a blueprint for future studies on the shared dynamics of the brain and ovarian function and a fundamental stepping stone towards developing sex-specific strategies to improve brain health and mental health.

Item Type:	Journal article
Publication Title:	Nature Mental Health
Creators:	Zsido, R.G., Williams, A.N., Barth, C., Serio, B., Kurth, L., Mildner, T., Trampel, R., Beyer, F., Witte, A.V., Villringer, A. and Sacher, J.
Publisher:	Springer Science and Business Media LLC
Date:	5 October 2023
Volume:	1
Number:	10
ISSN:	2731-6076
Identifiers:	Number Type 10.1038/s44220-023-00125-w DOI 1817633 Other
Rights:	© The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Divisions:	Schools > School of Social Sciences
Record created by:	Laura Ward
Date Added:	10 Oct 2023 08:01
Last Modified:	10 Nov 2023 11:28
URI:	https://irep.ntu.ac.uk/id/eprint/49932

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