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Ma, L, Huo, Y, Peng, T, Liu, Z, Ye, J, Chen, L, Wu, D, Du, W 
ORCID: https://orcid.org/0000-0002-5115-7214 and Chen, J,
2024.
Assessing the journey of calcium supplementation: a mendelian randomization study on the causal link between calcium levels and sleep disorders.
Clinical Nutrition ESPEN, 59, pp. 1-8.
ISSN 2405-4577
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Abstract
Background & Aim: Sleep disorder is a growing concern, and calcium supplementation is often recommended as a potential intervention for sleep disorders. However, the causal relationship between calcium levels and the incidence of sleep disorders remains unclear. Mendelian randomization techniques utilizing genetic variants that affect calcium levels, can provide valuable insights into causality. This study aims to examine the association between calcium levels and sleep disorders in a diverse population that includes both adolescents and adults, and investigate the effects of calcium levels on sleep disorders.
Methods: Mendelian randomization analysis was conducted using data from UK Biobank and FinnGen datasets. The inverse-variance weighting (IVW) was selected as the primary method. In addition, traditional mediation analysis was performed on a subset of the NHANES data spanning from 2007 to 2018.
Results: Our findings provide evidence supporting a causal relationship between calcium intake and reduced risk of sleep disorders (beta = -0.079, SE = 0.0395, P = 0.0457). While not reaching statistical significance, other MR methods such as weighted median and Mr-Egger exhibited similar directional trends. Analysis of the NHANES cohort revealed a negative association between calcium levels and the prevalence of sleep disorders in male, black, and physically active populations. However, this association was not observed in other demographic groups.
Conclusion: Our results suggested that there is no significant correlation between calcium levels and sleep disorder in non-exercise populations. This raises concerns about the long-term high-dose calcium supplementation in clinical practice, which requires further investigation.
| Item Type: | Journal article |
|---|---|
| Alternative Title: | How far do we have to go on the road to calcium supplementation? |
| Publication Title: | Clinical Nutrition ESPEN |
| Creators: | Ma, L., Huo, Y., Peng, T., Liu, Z., Ye, J., Chen, L., Wu, D., Du, W. and Chen, J. |
| Publisher: | Elsevier BV |
| Date: | February 2024 |
| Volume: | 59 |
| ISSN: | 2405-4577 |
| Identifiers: | Number Type 10.1016/j.clnesp.2023.10.039 DOI 1836904 Other |
| Divisions: | Schools > School of Social Sciences |
| Record created by: | Laura Ward |
| Date Added: | 17 Nov 2023 14:29 |
| Last Modified: | 15 Nov 2024 03:00 |
| URI: | https://irep.ntu.ac.uk/id/eprint/50394 |
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