Preconceptional capsaicin intervention mitigates negative effects of paternal obesity on metabolic characteristics in male offspring upon high-fat diet challenge

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Hu, J, Lin, Z, Yang, Y, Christian, M ORCID: https://orcid.org/0000-0002-1616-4179, Li, S, Zheng, B, Tan, BK and Lin, S, 2024. Preconceptional capsaicin intervention mitigates negative effects of paternal obesity on metabolic characteristics in male offspring upon high-fat diet challenge. Journal of Functional Foods, 116: 106137. ISSN 1756-4646

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Official URL: https://doi.org/10.1016/j.jff.2024.106137

Abstract

The activation of brown adipose tissue by cold exposure in paternal mice has been reported to improve the metabolic health of offspring. Notably, dietary components for activating BAT have drawn considerable attention owing to their high feasibility for human trials. Therefore, here the potential metabolic improving effects of dietary capsaicin intervention on diet-induced obese paternal mice and their offspring were measured. The results support that paternal preconceptional capsaicin intervention not only elicited the anticipated enhancement of brown fat activity in obese paternal mice, but also improved the metabolic profiles in male offspring evidenced by their elevated resistance to high-fat diet challenge. Moreover, changes in sperm DNA methylation and small non-coding RNA profile were noted in paternal mice with capsaicin intervention, though additional investigation is needed to further delve into the mechanisms. In summary, paternal dietary intervention activating BAT could represent a promising strategy for enhancing the metabolic health of offspring.

Item Type:	Journal article
Publication Title:	Journal of Functional Foods
Creators:	Hu, J., Lin, Z., Yang, Y., Christian, M., Li, S., Zheng, B., Tan, B.K. and Lin, S.
Publisher:	Elsevier BV
Date:	May 2024
Volume:	116
ISSN:	1756-4646
Identifiers:	Number Type 10.1016/j.jff.2024.106137 DOI 1875785 Other
Rights:	© 2024 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Divisions:	Schools > School of Science and Technology
Record created by:	Laura Ward
Date Added:	20 Mar 2024 09:43
Last Modified:	20 Mar 2024 09:43
URI:	https://irep.ntu.ac.uk/id/eprint/51123