Yin, B, Gosecka, M, Bodaghi, M ORCID: https://orcid.org/0000-0002-0707-944X, Crespy, D, Youssef, G, Dodda, JM, Wong, SHD, Imran, AB, Gosecki, M, Jobdeedamrong, A, Afzali Naniz, M and Zolfagharian, A, 2024. Engineering multifunctional dynamic hydrogel for biomedical and tissue regenerative applications. Chemical Engineering Journal, 487: 150403. ISSN 1385-8947
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Abstract
Hydrogels have emerged in various biomedical applications, including tissue engineering and medical devices, due to their ability to imitate the natural extracellular matrix (ECM) of tissues. However, conventional static hydrogels lack the ability to dynamically respond to changes in their surroundings to withstand the robust changes of the biophysical microenvironment and to trigger on-demand functionality such as drug release and mechanical change. In contrast, multifunctional dynamic hydrogels can adapt and respond to external stimuli and have drawn great attention in recent studies. It is realized that the integration of nanomaterials into dynamic hydrogels provides numerous functionalities for a great variety of biomedical applications that cannot be achieved by conventional hydrogels. This review article provides a comprehensive overview of recent advances in designing and fabricating dynamic hydrogels for biomedical applications. We describe different types of dynamic hydrogels based on breakable and reversible covalent bonds as well as noncovalent interactions. These mechanisms are described in detail as a useful reference for designing crosslinking strategies that strongly influence the mechanical properties of the hydrogels. We also discuss the use of dynamic hydrogels and their potential benefits. This review further explores different biomedical applications of dynamic nanocomposite hydrogels, including their use in drug delivery, tissue engineering, bioadhesives, wound healing, cancer treatment, and mechanistic study, as well as multiple-scale biomedical applications. Finally, we discuss the challenges and future perspectives of dynamic hydrogels in the field of biomedical engineering, including the integration of diverse technologies.
Item Type: | Journal article |
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Publication Title: | Chemical Engineering Journal |
Creators: | Yin, B., Gosecka, M., Bodaghi, M., Crespy, D., Youssef, G., Dodda, J.M., Wong, S.H.D., Imran, A.B., Gosecki, M., Jobdeedamrong, A., Afzali Naniz, M. and Zolfagharian, A. |
Publisher: | Elsevier BV |
Date: | 1 May 2024 |
Volume: | 487 |
ISSN: | 1385-8947 |
Identifiers: | Number Type 10.1016/j.cej.2024.150403 DOI 1881306 Other |
Rights: | © 2024 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
Divisions: | Schools > School of Science and Technology |
Record created by: | Laura Ward |
Date Added: | 03 Apr 2024 09:09 |
Last Modified: | 03 Apr 2024 09:09 |
URI: | https://irep.ntu.ac.uk/id/eprint/51187 |
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