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Ren, T, Zhang, L, Liu, Y, Zhang, Q, Sun, Y, Zhou, W, Huang, L, Wang, M, Pu, Y, Huang, R, Chen, J, He, H, Zhu, T, Wang, S, Chen, W, Zhang, Q, Du, W 
ORCID: https://orcid.org/0000-0002-5115-7214, Luo, Q and Li, F,
2024.
Sex-specific associations of adolescent motherhood with cognitive function, behavioral problems, and autistic-like traits in offspring and the mediating roles of family conflict and altered brain structure.
BMC Medicine, 22: 226.
ISSN 1741-7015
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Abstract
Background: Previous studies have linked adolescent motherhood to adverse neurodevelopmental outcomes in offspring, yet the sex-specific effect and underlying mechanisms remain unclear.
Methods: This study included 6952 children aged 9–11 from the Adolescent Brain Cognitive Development study. The exposed group consisted of children of mothers < 20 years at the time of birth, while the unexposed group was composed of children of mothers aged 20–35 at birth. We employed a generalized linear mixed model to investigate the associations of adolescent motherhood with cognitive, behavioral, and autistic-like traits in offspring. We applied an inverse-probability-weighted marginal structural model to examine the potential mediating factors including adverse perinatal outcomes, family conflict, and brain structure alterations.
Results: Our results revealed that children of adolescent mothers had significantly lower cognitive scores (β, − 2.11, 95% CI, − 2.90 to − 1.31), increased externalizing problems in male offspring (mean ratio, 1.28, 95% CI, 1.08 to 1.52), and elevated internalizing problems (mean ratio, 1.14, 95% CI, 0.99 to 1.33) and autistic-like traits (mean ratio, 1.22, 95% CI, 1.01 to 1.47) in female. A stressful family environment mediated ~ 70% of the association with internalizing problems in females, ~ 30% with autistic-like traits in females, and ~ 20% with externalizing problems in males. Despite observable brain morphometric changes related to adolescent motherhood, these did not act as mediating factors in our analysis, after adjusting for family environment. No elevated rate of adverse perinatal outcomes was observed in the offspring of adolescent mothers in this study.
Conclusions: Our results reveal distinct sex-specific neurodevelopmental outcomes impacts of being born to adolescent mothers, with a substantial mediating effect of family environment on behavioral outcomes. These findings highlight the importance of developing sex-tailored interventions and support the hypothesis that family environment significantly impacts the neurodevelopmental consequences of adolescent motherhood.
| Item Type: | Journal article |
|---|---|
| Publication Title: | BMC Medicine |
| Creators: | Ren, T., Zhang, L., Liu, Y., Zhang, Q., Sun, Y., Zhou, W., Huang, L., Wang, M., Pu, Y., Huang, R., Chen, J., He, H., Zhu, T., Wang, S., Chen, W., Zhang, Q., Du, W., Luo, Q. and Li, F. |
| Publisher: | Springer |
| Date: | 5 June 2024 |
| Volume: | 22 |
| ISSN: | 1741-7015 |
| Identifiers: | Number Type 10.1186/s12916-024-03442-8 DOI 1902223 Other |
| Rights: | © the author(s) 2024. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
| Divisions: | Schools > School of Social Sciences |
| Record created by: | Jonathan Gallacher |
| Date Added: | 10 Jun 2024 14:21 |
| Last Modified: | 10 Jun 2024 14:21 |
| URI: | https://irep.ntu.ac.uk/id/eprint/51544 |
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