Arterial stiffness after 6 weeks postdelivery in women with a history of hypertensive disorders of pregnancy: a systematic review protocol

Mbongozi, X, Galloway, S, Hunter, A ORCID: https://orcid.org/0000-0001-7562-6145 and Businge, CB, 2024. Arterial stiffness after 6 weeks postdelivery in women with a history of hypertensive disorders of pregnancy: a systematic review protocol. BMJ Open, 14 (9): e082424. ISSN 2044-6055

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Abstract

Introduction: Hypertensive disorders of pregnancy (HDP) are one of the leading causes of maternal morbidity and mortality. The risk of developing cardiovascular diseases following HDP is high. Arterial stiffness is a prognostic indicator for cardiovascular disease in the general population, and it is elevated during pregnancy in women with HDP. No systematic reviews have been conducted to determine if arterial stiffness remains elevated beyond puerperium in these women with HDP.

Methods and analysis: We will conduct a systematic literature search in the following electronic databases: Medline, PubMed, Embase, Cochrane Library, Google Scholar, Web of Science and CINAHL. The review will consider studies that investigate arterial stiffness in women who had HPD and are between 43 days and 10 years postdelivery and under 60 years of age. This systematic review will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols guidelines. Estimates of mean ± SD for arterial stiffness indices (cfPWV, AIx and AIx@75) for the women in the included studies will be obtained. For studies where the estimates were reported as the median and IQR, approximate estimates of mean ± SD will be calculated by using the low and high end of the range, median and sample size. Data from the individual studies will be pooled by use of a random-effects model. The risk of bias assessment will be assessed using the Cochrane Collaboration tool and the Newcastle-Ottawa Quality Assessment Scale as appropriate. Sources of heterogeneity will be explored by sensitivity and subgroup analyses.

Ethics and dissemination: No ethics approval is required as only published data will be used in this study. The research study’s outcomes will be shared through scientific conferences and peer-reviewed publications.

Item Type:	Journal article
Publication Title:	BMJ Open
Creators:	Mbongozi, X., Galloway, S., Hunter, A. and Businge, C.B.
Publisher:	BMJ
Date:	September 2024
Volume:	14
Number:	9
ISSN:	2044-6055
Identifiers:	Number Type 10.1136/bmjopen-2023-082424 DOI 2266123 Other
Rights:	© Author(s) (or their employer(s)) 2024. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
Divisions:	Schools > School of Science and Technology
Record created by:	Laura Ward
Date Added:	16 Dec 2024 09:56
Last Modified:	16 Dec 2024 09:56
URI:	https://irep.ntu.ac.uk/id/eprint/52724

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