Interaction between bacterial adhesins leads to coaggregation by the oral bacteria Veillonella parvula and Streptococcus gordonii

Leo, JC ORCID logoORCID: https://orcid.org/0000-0002-7066-7527, 2025. Interaction between bacterial adhesins leads to coaggregation by the oral bacteria Veillonella parvula and Streptococcus gordonii. mBio. ISSN 2150-7511

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Abstract

Veillonella parvula is an unusual diderm firmicute that plays a central role in the formation of dental biofilm formation through coaggregation with many other oral bacteria. However, the molecular interactions leading to oral biofilm formation are largely unknown. In a recent study (L. Dorison, N. Béchon, C. Martin-Gallausiaux, S. Chamorro-Rodriguez, et al., mBio 15:e02171-24, 2024, https://doi.org/10.1128/mbio.02171-24), coaggregation by V. parvula was shown to be mediated by trimeric autotransporter adhesins (TAAs), which are large, fibrous surface proteins widespread in Gram-negative bacteria. Importantly, this study identified the binding partner protein on a coaggregating bacterium, Streptococcus gordonii, which the authors called VisA. This finding is the first time a TAA mediating coaggregation with a different type of protein has been established and suggests that specifically interacting protein partners may have coevolved multiple times to allow complex biofilm formation, as exemplified by the development of dental plaque. Understanding these interactions might lead to innovations to reduce build-up of dental plaque and associated oral diseases.

Item Type: Journal article
Publication Title: mBio
Creators: Leo, J.C.
Publisher: American Society for Microbiology
Date: 10 January 2025
ISSN: 2150-7511
Identifiers:
Number
Type
10.1128/mbio.03279-24
DOI
2340922
Other
Divisions: Schools > School of Science and Technology
Record created by: Jeremy Silvester
Date Added: 16 Jan 2025 09:17
Last Modified: 16 Jan 2025 09:17
URI: https://irep.ntu.ac.uk/id/eprint/52856

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