Disruption of functional network development in children with prenatal Zika virus exposure revealed by resting-state EEG

Omurtag, A ORCID: https://orcid.org/0000-0002-3773-8506, Abdulbaki, S, Thesen, T, Waechter, R, Landon, B, Evans, R, Dlugos, D, Chari, G, LaBeaud, AD, Hassan, YI, Fernandes, M and Blackmon, K, 2025. Disruption of functional network development in children with prenatal Zika virus exposure revealed by resting-state EEG. Scientific Reports, 15: 6346. ISSN 2045-2322

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Abstract

Children born to mothers infected by Zika virus (ZIKV) during pregnancy are at increased risk of adverse neurodevelopmental outcomes including microcephaly, epilepsy, and neurocognitive deficits, collectively known as Congenital Zika Virus Syndrome. To study the impact of ZIKV on infant brain development, we collected resting-state electroencephalography (EEG) recordings from 28 normocephalic ZIKV-exposed children and 16 socio-demographically similar but unexposed children at 23–27 months of age. We assessed group differences in frequency band power and brain synchrony, as well as the relationship between these metrics and age. A significant difference (p < 0.05, Bonferroni corrected) in Inter-Site Phase Coherence was observed: median Pearson correlation coefficients were 0.15 in unexposed children and 0.07 in ZIKV-exposed children. Results showed that functional brain networks in the unexposed group were developing rapidly, in part by strengthening distal high-frequency and weakening proximal lower frequency connectivity, presumably reflecting normal synaptic growth, myelination and pruning. These maturation patterns were attenuated in the ZIKV-exposed group, suggesting that ZIKV exposure may contribute to neurodevelopmental vulnerabilities that can be detected and quantified by resting-state EEG.

Item Type:	Journal article
Publication Title:	Scientific Reports
Creators:	Omurtag, A., Abdulbaki, S., Thesen, T., Waechter, R., Landon, B., Evans, R., Dlugos, D., Chari, G., LaBeaud, A.D., Hassan, Y.I., Fernandes, M. and Blackmon, K.
Publisher:	Springer Science and Business Media LLC
Date:	21 February 2025
Volume:	15
ISSN:	2045-2322
Identifiers:	Number Type 10.1038/s41598-025-90860-0 DOI 2384019 Other
Divisions:	Schools > School of Science and Technology
Record created by:	Melissa Cornwell
Date Added:	24 Feb 2025 11:02
Last Modified:	24 Feb 2025 11:02
URI:	https://irep.ntu.ac.uk/id/eprint/53120

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