Non-porous silica nanoparticles as a cavitation sensitive vehicle for antibiotic delivery

Ball, G, Stevenson, J, Boroujeni, FA, Jacobson, B, Kuehne, SA ORCID: https://orcid.org/0000-0001-6790-8433, Lucas, M, Walmsley, AD, Prentice, P and Pikramenou, Z, 2025. Non-porous silica nanoparticles as a cavitation sensitive vehicle for antibiotic delivery. Ultrasonics Sonochemistry. ISSN 1350-4177

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Abstract

Ultrasound stimulated drug delivery is attractive for controlled dose and localised delivery to reduce excess loss of drug and side effects, which for antibiotics is pertinent to the fight against antimicrobial resistance. Low frequency ultrasound is commonly used in dental clinical practice for bacterial biofilm removal and is an attractive versatile stimulus for drug release. Here we introduce nonporous silica nanoparticles (or amorphous) as a biocompatible, encapsulant for triggered drug release by low frequency ultrasound. A 20 kHz ultrasonic sonotrode is used in to evaluate the release of the antibiotic ciprofloxacin, CPX from non-porous particles, CPX⊂SiO2. Laser doppler vibrometry (LDV) was employed to characterise the ultrasonic vibration displacement of the sonotrode. Drug release from CPX⊂SiO2 was monitored for increasing the tip displacement and found to dispense clinically relevant quantities of CPX release (5.7 mg/L), even at low amplitudes (40 µm). A strong correlation was observed between cavitation features in the acoustic spectra and drug release from CPX⊂SiO2. Silica nanoparticles with and without encapsulated CPX, CPX⊂SiO2 and SiO2, respectively, were found to promote cavitation at lower amplitudes confirmed by high-speed imaging, in contrast to mesoporous particles with and without adsorbed CPX, CPX@m-SiO2 and m-SiO2. Spectra of the emissions collected via an acoustic cavitation detector supported these results. Our studies demonstrate a novel platform for drug delivery employing low frequency ultrasound for synergistic enhancement of cavitation effects and triggered drug release.

Item Type:	Journal article
Publication Title:	Ultrasonics Sonochemistry
Creators:	Ball, G., Stevenson, J., Boroujeni, F.A., Jacobson, B., Kuehne, S.A., Lucas, M., Walmsley, A.D., Prentice, P. and Pikramenou, Z.
Publisher:	Elsevier
Date:	17 March 2025
ISSN:	1350-4177
Identifiers:	Number Type 10.1016/j.ultsonch.2025.107316 DOI 2409720 Other
Divisions:	Schools > School of Science and Technology
Record created by:	Laura Borcherds
Date Added:	19 Mar 2025 09:30
Last Modified:	19 Mar 2025 09:30
URI:	https://irep.ntu.ac.uk/id/eprint/53272

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