Drug resistance of Mycobacterium tuberculosis to linezolid and delamanid: a case report from Bukavu, Democratic Republic of Congo

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Bisimwa, BC, Bahizire, E, Kiselinova, M, Byela, V, Ngabonziza, JCS, Hakizayezu, F, Runyambo, D, Meehan, CJ ORCID: https://orcid.org/0000-0003-0724-8343, Mulders, W, Cuella-Martin, I, Rigouts, L, Birembano, F, Callens, S, de Jong, BC and Kaswa, M, 2025. Drug resistance of Mycobacterium tuberculosis to linezolid and delamanid: a case report from Bukavu, Democratic Republic of Congo. BMC Infectious Diseases, 25: 913. ISSN 1471-2334

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Official URL: https://doi.org/10.1186/s12879-025-11348-w

Abstract

The emergence of resistance is of great concern in the control of TB, especially to the new and repurposed drugs needed for the treatment of rifampicin resistance. We report a patient from South Kivu in the Eastern Democratic Republic of the Congo with primary resistance to delamanid and linezolid without treatment experience with these drugs. The identification of novel resistance mutations raises concerns about the potential global spread and poor outcomes of the WHO-recommended oral treatment regimens, highlighting the need for the urgent rollout of DST.

Item Type:	Journal article
Publication Title:	BMC Infectious Diseases
Creators:	Bisimwa, B.C., Bahizire, E., Kiselinova, M., Byela, V., Ngabonziza, J.C.S., Hakizayezu, F., Runyambo, D., Meehan, C.J., Mulders, W., Cuella-Martin, I., Rigouts, L., Birembano, F., Callens, S., de Jong, B.C. and Kaswa, M.
Publisher:	Springer Science and Business Media LLC
Date:	12 July 2025
Volume:	25
ISSN:	1471-2334
Identifiers:	Number Type 10.1186/s12879-025-11348-w DOI 2487846 Other
Rights:	© The Author(s) 2025. This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creati vecommons.org/licenses/by-nc-nd/4.0/
Divisions:	Schools > School of Science and Technology
Record created by:	Jeremy Silvester
Date Added:	21 Aug 2025 08:29
Last Modified:	21 Aug 2025 08:29
URI:	https://irep.ntu.ac.uk/id/eprint/54238