Genetically engineered peptides for the biomimetic mineralisation of metal-organic frameworks

Lymperopoulou, S, Hoff, S, Sola-Rabada, A, Michaelis, M, Efimov, I, Westcott, ZC, Willimott, IJ, Chiacchia, M, Heinz, H, Perry, CC ORCID: https://orcid.org/0000-0003-1517-468X and Bradshaw, D, 2025. Genetically engineered peptides for the biomimetic mineralisation of metal-organic frameworks. Chem. ISSN 2451-9308 (Forthcoming)

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Abstract

Biomimetic mineralisation of metal -organic frameworks (MOFs) is a promising synthetic strategy for MOF and hybrid bio-MOF composites with significant potential in a variety of applications. While interactions of MOFs with several biological materials have been well-studied, interactions with peptides remain unexplored. Here we use phage display to identify strongly-binding peptides for isoreticular MOFs (UiO-66 and UiO-66-NH2). Zeta potential and CD spectroscopy measurements combined with MD simulations permit characterization and explanation of the structure and dynamics of the MOF binding peptides, and differences in conformation and binding coefficients, allowing the MOF-peptide recognition mechanisms to be determined. The peptides have been successfully used to control MOF crystallinity and morphology for UiO-X MOFs, from a synthesis where amorphous products form in their absence. The findings presented have significant implications for understanding MOF-peptide interactions, which will be critical for the design and control over MOF structures and for bio-centered applications in the future.

Item Type:	Journal article
Publication Title:	Chem
Creators:	Lymperopoulou, S., Hoff, S., Sola-Rabada, A., Michaelis, M., Efimov, I., Westcott, Z.C., Willimott, I.J., Chiacchia, M., Heinz, H., Perry, C.C. and Bradshaw, D.
Publisher:	Cell Press
Date:	17 November 2025
ISSN:	2451-9308
Identifiers:	Number Type 2550822 Other
Rights:	This accepted manuscript is shared under a CC-BY-NC-ND license after a 12 month embargo period.
Divisions:	Schools > School of Science and Technology
Record created by:	Melissa Cornwell
Date Added:	09 Jan 2026 13:19
Last Modified:	09 Jan 2026 13:19
URI:	https://irep.ntu.ac.uk/id/eprint/55007

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