Identification of novel molecular drivers, prognostic and diagnostic biomarkers for inflammatory bowel disease (IBD): protocol for the Nottingham/AstraZeneca prospective IBD observational cohort study

Serna-Valverde, AL, Rodriguez-Suarez, E, Marks, DJB, Gehrmann, U, Neisen, J, Clarke, S, Chew, TS, Cummings, F, De Silva, S, Gordon, JN, Knight, P, Limdi, J, Patel, K, Crooks, B, Sebastian, S, Polytarchou, C ORCID: https://orcid.org/0000-0002-1948-7934, Hannan, NRF and Moran, GW, 2025. Identification of novel molecular drivers, prognostic and diagnostic biomarkers for inflammatory bowel disease (IBD): protocol for the Nottingham/AstraZeneca prospective IBD observational cohort study. BMJ Open, 15 (11): e105790. ISSN 2044-6055

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Abstract

Introduction: Crohn’s disease (CD) and ulcerative colitis (UC) are chronic, inflammatory bowel diseases (IBDs) of unknown origin, affecting the gastrointestinal tract and often causing extraintestinal symptoms. Conventional treatments (eg, glucocorticosteroids, immunomodulators) and targeted advanced treatments, including anti-TNFα, antibodies to p40 subunit of IL-12/23, antibodies to p19 subunit of IL-23, anti-α4β7 integrin, Janus kinase inhibitors (JAKis) and sphingosine-1-phosphate receptor (S1PR) modulators, do not achieve sustained responses for all patients, leaving significant unmet therapeutic needs.

Methods and analysis: This prospective, multi-centre observational study will follow a cohort of 240 patients across multiple study centres within NHS trusts in the UK who are initiating or switching biologics, specifically anti-TNFα and anti-α4β7 integrin for UC, and anti-TNFα, antibodies to p40 subunit of IL-12/2 and JAKi for CD. Through comprehensive profiling of immunological, transcriptional, microbiome, genetic and proteomic markers at baseline, week 12, and week 52, this study aims to uncover non-invasive biomarkers that predict response to these drug classes, ultimately advancing personalised medicine in IBD.

Ethics and dissemination: Ethical approval for the Nottingham/AstraZeneca study was granted by the West of Scotland Research Ethics Committee. Recruitment began in December 2022 and is currently ongoing at 10 NHS Trust sites across the UK. Study findings will be disseminated by publication in peer-reviewed journals and presentations at relevant national and international conferences.

Item Type:	Journal article
Publication Title:	BMJ Open
Creators:	Serna-Valverde, A.L., Rodriguez-Suarez, E., Marks, D.J.B., Gehrmann, U., Neisen, J., Clarke, S., Chew, T.S., Cummings, F., De Silva, S., Gordon, J.N., Knight, P., Limdi, J., Patel, K., Crooks, B., Sebastian, S., Polytarchou, C., Hannan, N.R.F. and Moran, G.W.
Publisher:	BMJ
Date:	November 2025
Volume:	15
Number:	11
ISSN:	2044-6055
Identifiers:	Number Type 10.1136/bmjopen-2025-105790 DOI 2565456 Other
Rights:	© author(s) (or their employer(s)) 2025. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made (https://creativecommons.org/licenses/by/4.0/.)
Divisions:	Schools > School of Science and Technology
Record created by:	Jonathan Gallacher
Date Added:	03 Feb 2026 13:22
Last Modified:	03 Feb 2026 13:22
URI:	https://irep.ntu.ac.uk/id/eprint/55173

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