Parallel independent evolution of pathogenicity within the genus Yersinia

Reuter, S, Connor, TR, Barquist, L, Walker, D, Feltwell, T, Harris, SR, Fookes, M, Hall, ME, Petty, NK, Fuchs, TM, Corander, J, Dufour, M, Ringwood, T, Savin, C, Bouchier, C, Martin, L, Miettinen, M, Shubin, M, Riehm, JM, Laukkanen-Ninios, R, Sihvonen, LM, Siitonen, A, Skurnik, M, Falcão, JP, Fukushima, H, Scholz, HC, Prentice, MB, Wren, BW, Parkhill, J, Carniel, J, Achtman, M, McNally, A ORCID: https://orcid.org/0000-0002-3099-630X and Thomson, NR, 2014. Parallel independent evolution of pathogenicity within the genus Yersinia. Proceedings of the National Academy of Sciences of the United States of America, 111 (18), pp. 6768-6773. ISSN 0027-8424

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Abstract

The genus Yersinia has been used as a model system to study pathogen evolution. Using whole-genome sequencing of all Yersinia species, we delineate the gene complement of the whole genus and define patterns of virulence evolution. Multiple distinct ecological specializations appear to have split pathogenic strains from environmental, nonpathogenic lineages. This split demonstrates that contrary to hypotheses that all pathogenic Yersinia species share a recent common pathogenic ancestor, they have evolved independently but followed parallel evolutionary paths in acquiring the same virulence determinants as well as becoming progressively more limited metabolically. Shared virulence determinants are limited to the virulence plasmid pYV and the attachment invasion locusail. These acquisitions, together with genomic variations in metabolic pathways, have resulted in the parallel emergence of related pathogens displaying an increasingly specialized lifestyle with a spectrum of virulence potential, an emerging theme in the evolution of other important human pathogens.

Item Type:	Journal article
Publication Title:	Proceedings of the National Academy of Sciences of the United States of America
Creators:	Reuter, S., Connor, T.R., Barquist, L., Walker, D., Feltwell, T., Harris, S.R., Fookes, M., Hall, M.E., Petty, N.K., Fuchs, T.M., Corander, J., Dufour, M., Ringwood, T., Savin, C., Bouchier, C., Martin, L., Miettinen, M., Shubin, M., Riehm, J.M., Laukkanen-Ninios, R., Sihvonen, L.M., Siitonen, A., Skurnik, M., Falcão, J.P., Fukushima, H., Scholz, H.C., Prentice, M.B., Wren, B.W., Parkhill, J., Carniel, J., Achtman, M., McNally, A. and Thomson, N.R.
Publisher:	National Academy of Sciences
Date:	2014
Volume:	111
Number:	18
ISSN:	0027-8424
Identifiers:	Number Type 10.1073/pnas.1317161111 DOI
Rights:	Copyright © 2014 National Academy of Sciences
Divisions:	Schools > School of Science and Technology
Record created by:	EPrints Services
Date Added:	09 Oct 2015 10:00
Last Modified:	09 Jun 2017 13:16
URI:	https://irep.ntu.ac.uk/id/eprint/6155

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