Approaching intelligent infection diagnostics: carbon fibre sensor for electrochemical pyocyanin detection

Sharp, D, Gladstone, P, Smith, RB, Forsythe, S ORCID: https://orcid.org/0000-0002-6709-0712 and Davis, J, 2010. Approaching intelligent infection diagnostics: carbon fibre sensor for electrochemical pyocyanin detection. Bioelectrochemistry, 77 (2), pp. 114-119. ISSN 1567-5394

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Abstract

The pertinence of exploiting carbon fibre tow as an electrochemical sensing matrix for assessing pyocyanin production is evaluated. Pyocyanin is released by Ps. aeruginosa as a quorum signalling molecule during wound colonisation, increasing virulence and damaging host physiology, both contributing to an increased risk of infection. Prototype sensor assemblies have been developed and response characteristics towards pyocyanin are detailed. Sensitive and precise electrochemical measurements of pyocyanin by square wave voltammetry are established that enable the periodic monitoring of wound exudates for the presence of pyocyanin and serve as an early/pre-infection marker. As such, the pyocyanin sensor is presented as a possible sensor for intelligent wound management though incorporation into a 'smart-bandage' assembly or for use as a Point of Care Test for detection of Ps aeruginosa in cystic fibrosis patients' sputa.

Item Type:	Journal article
Publication Title:	Bioelectrochemistry
Creators:	Sharp, D., Gladstone, P., Smith, R.B., Forsythe, S. and Davis, J.
Publisher:	Elsevier
Date:	2010
Volume:	77
Number:	2
ISSN:	1567-5394
Identifiers:	Number Type 10.1016/j.bioelechem.2009.07.008 DOI
Rights:	Copyright © 2010 Elsevier B.V. All rights reserved.
Divisions:	Schools > School of Science and Technology
Record created by:	EPrints Services
Date Added:	09 Oct 2015 10:05
Last Modified:	09 Jun 2017 13:18
URI:	https://irep.ntu.ac.uk/id/eprint/7574

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