Adjunctive quetiapine for serotonin reuptake inhibitor-resistant obsessive-compulsive disorder: A meta-analysis of randomised controlled treatment trials

Fineberg, N, Stein, DJ, Premkumar, P ORCID: https://orcid.org/0000-0003-1934-6741, Carey, P, Sivakumaran, T, Vythilingum, B, Seedat, S, Westenberg, H and Denys, D, 2006. Adjunctive quetiapine for serotonin reuptake inhibitor-resistant obsessive-compulsive disorder: A meta-analysis of randomised controlled treatment trials. International Clinical Psychopharmacology, 21, pp. 337-343.

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Abstract

Small studies have shown positive effects from adding a variety of antipsychotic agents in patients with obsessive–compulsive disorder who are unresponsive to treatment with serotonin reuptake inhibitors. The evidence, however, is contradictory. This paper reports a meta-analysis of existing double-blind randomized placebo-controlled studies looking at the addition of the second-generation antipsychotic quetiapine in such cases. Three studies fulfilled the inclusion criteria. Altogether 102 individuals were subjected to analysis using Review Manager (4.2.7). The results showed evidence of efficacy for adjunctive quetiapine (< 400 mg/day) on the primary efficacy criterion, measured as changes from baseline in total Yale–Brown Obsessive Compulsive Scale scores (P = 0.008), the clinical significance of which was limited by between-study heterogeneity. The mechanism underlying the effect may involve serotonin and/or dopamine neurotransmission.

Item Type:	Journal article
Description:	Published in: FINEBERG, N., STEIN, D.J., PREMKUMAR, P., CAREY, P., SIVAKUMARAN, T., VYTHILINGUM, B., SEEDAT, S., WESTENBERG, H. and DENYS, D., 2006. Adjunctive quetiapine for serotonin reuptake inhibitor-resistant obsessive-compulsive disorder: A meta-analysis of randomised controlled treatment trials. International Clinical Psychopharmacology, 21, pp. 337-343.
Publication Title:	International Clinical Psychopharmacology
Creators:	Fineberg, N., Stein, D.J., Premkumar, P., Carey, P., Sivakumaran, T., Vythilingum, B., Seedat, S., Westenberg, H. and Denys, D.
Publisher:	Lippincott, Williams and Wilkins
Date:	2006
Volume:	21
Identifiers:	Number Type 10.1097/01.yic.0000215083.57801.11 DOI
Rights:	Copyright © 2006 Lippincott Williams & Wilkins.
Divisions:	Schools > School of Social Sciences
Record created by:	EPrints Services
Date Added:	09 Oct 2015 10:07
Last Modified:	09 Jun 2017 13:19
URI:	https://irep.ntu.ac.uk/id/eprint/8030

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