Preliminary investigation of the effects of long-term dietary intake of genistein and daidzein on hepatic histopathology and biochemistry in domestic cats (Felis catus)

Whitehouse-Tedd, KM ORCID: https://orcid.org/0000-0003-0061-489X, Cave, NJ, Ugarte, CE, Roe, WD and Thomas, DG, 2012. Preliminary investigation of the effects of long-term dietary intake of genistein and daidzein on hepatic histopathology and biochemistry in domestic cats (Felis catus). Journal of Applied Animal Nutrition, 1, e3. ISSN 2049-257X

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Abstract

Dietary isoflavones have been hypothesised to play a role in hepatic veno-occlusive disease in captive exotic felids, although empirical evidence is lacking. This study aimed to investigate the effect of long-term (>1 year) dietary genistein and daidzein exposure on the hepatic biochemistry and histology of domestic cats. Individual cats were assessed for hepatic enzyme and bile acid production before and after the removal of isoflavones from their diet in the treatment group (n=4), and at the same times in unexposed control animals (n=7). No significant differences were detectable in hepatic biochemistry between treatment and control groups, and all serum values were within the normal reference ranges for domestic cats. Additionally, treatment animals demonstrated slightly greater areas of fibrosis surrounding hepatic venules than control animals, but this difference was not statistically significant. On the basis of the results presented, dietary isoflavones, at the current dose and duration of exposure do not appear to modulate hepatic enzyme production or histological parameters.

Item Type:	Journal article
Publication Title:	Journal of Applied Animal Nutrition
Creators:	Whitehouse-Tedd, K.M., Cave, N.J., Ugarte, C.E., Roe, W.D. and Thomas, D.G.
Publisher:	Cambridge University Press
Place of Publication:	Cambridge
Date:	2012
Volume:	1
ISSN:	2049-257X
Identifiers:	Number Type 10.1017/jan.2012.2 DOI
Divisions:	Schools > School of Animal, Rural and Environmental Sciences
Record created by:	EPrints Services
Date Added:	09 Oct 2015 10:09
Last Modified:	09 Jun 2017 13:20
URI:	https://irep.ntu.ac.uk/id/eprint/8498

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