Phylogeographic separation and formation of sexually discrete lineages in a global population of Yersinia pseudotuberculosis

Seecharran, T ORCID: https://orcid.org/0000-0002-9829-0792, Kalin-Manttari, L, Koskela, K, Nikkari, S, Dickins, B ORCID: https://orcid.org/0000-0002-0866-6232, Corander, J, Skurnik, M and McNally, A ORCID: https://orcid.org/0000-0002-3099-630X, 2017. Phylogeographic separation and formation of sexually discrete lineages in a global population of Yersinia pseudotuberculosis. Microbial Genomics. ISSN 2057-5858

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Abstract

Yersinia pseudotuberculosis is a Gram-negative intestinal pathogen of humans and has been responsible for several nationwide gastrointestinal outbreaks. Large-scale population genomic studies have been performed on the other human pathogenic species of the genus Yersinia, Yersinia pestis and Yersinia enterocolitica allowing a high-resolution understanding of the ecology, evolution and dissemination of these pathogens. However, to date no purpose-designed large-scale global population genomic analysis of Y. pseudotuberculosis has been performed. Here we present analyses of the genomes of 134 strains of Y. pseudotuberculosis isolated from around the world, from multiple ecosystems since the 1960s. Our data display a phylogeographic split within the population, with an Asian ancestry and subsequent dispersal of successful clonal lineages into Europe and the rest of the world. These lineages can be differentiated by CRISPR cluster arrays, and we show that the lineages are limited with respect to inter-lineage genetic exchange. This restriction of genetic exchange maintains the discrete lineage structure in the population despite co-existence of lineages for thousands of years in multiple countries. Our data highlights how CRISPR can be informative of the evolutionary trajectory of bacterial lineages, and merits further study across bacteria.

Item Type:	Journal article
Publication Title:	Microbial Genomics
Creators:	Seecharran, T., Kalin-Manttari, L., Koskela, K., Nikkari, S., Dickins, B., Corander, J., Skurnik, M. and McNally, A.
Publisher:	Microbiology Society
Date:	18 September 2017
ISSN:	2057-5858
Identifiers:	Number Type 10.1099/mgen.0.000133 DOI
Divisions:	Schools > School of Science and Technology
Record created by:	Linda Sullivan
Date Added:	09 Oct 2017 09:03
Last Modified:	04 Feb 2022 10:14
URI:	https://irep.ntu.ac.uk/id/eprint/31802

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