Targeting cellular pathways in glioblastoma multiforme

Pearson, JRD and Regad, T ORCID: https://orcid.org/0000-0003-4028-6368, 2017. Targeting cellular pathways in glioblastoma multiforme. Signal Transduction and Targeted Therapy, 2, e17040. ISSN 2059-3635

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Abstract

Glioblastoma multiforme (GBM) is a debilitating disease that is associated with poor prognosis, short median patient survival and a very limited response to therapies. GBM has a very complex pathogenesis that involves mutations and alterations of several key cellular pathways that are involved in cell proliferation, survival, migration and angiogenesis. Therefore, efforts that are directed toward better understanding of GBM pathogenesis are essential to the development of efficient therapies that provide hope and extent patient survival. In this review, we outline the alterations commonly associated with GBM pathogenesis and summarize therapeutic strategies that are aimed at targeting aberrant cellular pathways in GBM.

Item Type:	Journal article
Publication Title:	Signal Transduction and Targeted Therapy
Creators:	Pearson, J.R.D. and Regad, T.
Publisher:	Nature Publishing Group
Date:	29 September 2017
Volume:	2
ISSN:	2059-3635
Identifiers:	Number Type 10.1038/sigtrans.2017.40 DOI sigtrans201740 Publisher Item Identifier
Rights:	© The Author(s) 2017. This work is licensed under a Creative Commons Attribution 4.0 International License.
Divisions:	Schools > School of Science and Technology
Record created by:	Jonathan Gallacher
Date Added:	20 Oct 2017 09:19
Last Modified:	20 Oct 2017 09:21
URI:	https://irep.ntu.ac.uk/id/eprint/31842

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