Passive heating and glycaemic control in non-diabetic and diabetic individuals: a systematic review and meta-analysis

Maley, MJ, Hunt, AP, Stewart, IB, Faulkner, SH ORCID: https://orcid.org/0000-0003-4688-7252 and Minett, GM, 2019. Passive heating and glycaemic control in non-diabetic and diabetic individuals: a systematic review and meta-analysis. PLoS ONE, 14 (3): e0214223. ISSN 1932-6203

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Abstract

Objective: Passive heating (PH) has begun to gain research attention as an alternative therapy for cardio-metabolic diseases. Whether PH improves glycaemic control in diabetic and non-diabetic individuals is unknown. This study aims to review and conduct a meta-analysis of published literature relating to PH and glycaemic control.

Methods: Electronic data sources, PubMed, Embase and Web of Science from inception to July 2018 were searched for randomised controlled trials (RCT) studying the effect of PH on glycaemic control in diabetic or non-diabetic individuals. To measure the treatment effect, standardised mean differences (SMD) with 95 % confidence intervals (CI) were calculated.

Results: Fourteen articles were included in the meta-analysis. Following a glucose load, glucose concentration was greater during PH in non-diabetic (SMD 0.75, 95 % CI 1.02 to 0.48, P < 0.001) and diabetic individuals (SMD 0.27, 95 % CI 0.52 to 0.02, P = 0.030). In non-diabetic individuals, glycaemic control did not differ between PH and control only (SMD 0.11, 95 % CI 0.44 to -0.22, P > 0.050) and a glucose challenge given within 24 hours post-heating (SMD 0.30, 95 % CI 0.62 to -0.02, P > 0.050).

Conclusion: PH preceded by a glucose load results in acute glucose intolerance in non-diabetic and diabetic individuals. However, heating a non-diabetic individual without a glucose load appears not to affect glycaemic control. Likewise, a glucose challenge given within 24 hours of a single-bout of heating does not affect glucose tolerance in non-diabetic individuals. Despite the promise PH may hold, no short-term benefit to glucose tolerance is observed in non-diabetic individuals. More research is needed to elucidate whether this alternative therapy benefits diabetic individuals.

Item Type:	Journal article
Publication Title:	PLoS ONE
Creators:	Maley, M.J., Hunt, A.P., Stewart, I.B., Faulkner, S.H. and Minett, G.M.
Publisher:	Public Library of Science
Date:	22 March 2019
Volume:	14
Number:	3
ISSN:	1932-6203
Identifiers:	Number Type 10.1371/journal.pone.0214223 DOI
Divisions:	Schools > School of Science and Technology
Record created by:	Jonathan Gallacher
Date Added:	18 Mar 2019 11:35
Last Modified:	25 Mar 2019 09:57
URI:	https://irep.ntu.ac.uk/id/eprint/36060

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