Physiological consequences of the work of breathing and of inspiratory muscle training

Brown, P, 2009. Physiological consequences of the work of breathing and of inspiratory muscle training. PhD, Nottingham Trent University.

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Abstract

A reduced blood lactate concentration ([lac-]B) is commonly observed during whole-body exercise following inspiratory muscle training (IMT). However, whether the inspiratory muscles are, in part, the source of these reductions remains unknown. Accordingly, this thesis investigated: (I) the contribution of the respiratory muscles to the systemic [lac-]B and (II) the effects of IMT upon inspiratory muscle lactate exchange and clearance. In addition, the thesis also evaluated the determinants of inspiratory muscle strength (maximal inspiratory mouth pressure; MIP). All subjects were healthy, active and free of pulmonary and respiratory muscle disease. Under resting conditions, 10 min intense volitional hyperpnoea at 85% of maximal exercise minute ventilation (VE max) increased [lac-]B by 0.96 mmol.L-1. This was attenuated by 25% following 6 wks IMT. 8 min volitional hyperpnoea at 90% VE max imposed upon exercise at the maximal lactate steady state (MLSS) increased [lac-]B by 0.99 mmol.L-1. Following 6 wk IMT, the steady state and hyperpnoea-mediated increase in [lac-]B were lower by 8 and 26%, respectively. Relative to pre-IMT, loading the trained inspiratory muscles using a low-intensity pressure threshold resistance (15 cmH2O) immediately following maximal exercise accelerated both lactate exchange and clearance capacities by ~70%.

Item Type:	Thesis
Creators:	Brown, P.
Date:	2009
Rights:	This work is the intellectual property of the author, and may also be owned by the research sponsor(s) and/or Nottingham Trent University. You may copy up to 5% of this work for private study, or personal, non-commercial research. Any re-use of the information contained within this document should be fully referenced, quoting the author, title, university, degree level and pagination. Queries or requests for any other use, or if a more substantial copy is required, should be directed in the first instance to the author.
Divisions:	Schools > School of Science and Technology
Record created by:	EPrints Services
Date Added:	09 Oct 2015 09:33
Last Modified:	09 Oct 2015 09:33
URI:	https://irep.ntu.ac.uk/id/eprint/40

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