How does the polymer architecture and position of cationic charges affect cell viability?

Correia, JS, Miron Barroso, S, Hutchings, C, Ottaviani, S ORCID: https://orcid.org/0000-0002-8830-9947, Somuncuoğlu, B, Castellano, L, Porter, AE, Krell, J and Georgiou, TK, 2022. How does the polymer architecture and position of cationic charges affect cell viability? Polymer Chemistry. ISSN 1759-9954

Preview

Text 1627284_Ottaviani.pdf - Post-print Download (1MB) | Preview

Abstract

Polymer chemistry, composition and molar mass are factors that are known to affect cytotoxicity however the influence of polymer architecture has not been investigated systematically. In this study the influence of the position of the cationic charges along the polymer chain on cytotoxicity was investigated while keeping constant the other polymer characteristics. Specifically, copolymers of various architectures, based on a cationic pH responsive monomer, 2-(dimethylamino)ethyl methacrylate (DMAEMA) and a non-ionic hydrophilic monomer, oligo(ethylene glycol)methyl ether methacrylate (OEGMA) were engineered and their toxicity towards a panel of cell lines investigated. Of the seven different polymer architectures examined, the block-like structures were less cytotoxic than statistical or gradient/tapered architectures. These findings will assist in developing future vectors for nucleic acid delivery.

Item Type:	Journal article
Publication Title:	Polymer Chemistry
Creators:	Correia, J.S., Miron Barroso, S., Hutchings, C., Ottaviani, S., Somuncuoğlu, B., Castellano, L., Porter, A.E., Krell, J. and Georgiou, T.K.
Publisher:	Royal Society of Chemistry
Date:	7 December 2022
ISSN:	1759-9954
Identifiers:	Number Type 10.1039/d2py01012g DOI 1627284 Other
Rights:	This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License.
Divisions:	Schools > School of Science and Technology
Record created by:	Laura Ward
Date Added:	13 Dec 2022 10:21
Last Modified:	16 Dec 2022 10:52
URI:	https://irep.ntu.ac.uk/id/eprint/47641

Actions (login required)

Edit View

Statistics

Views

Downloads