Investigation of social and cognitive predictors in non-transition ultra-high-risk’ individuals for psychosis using spiking neural networks

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Doborjeh, Z, Doborjeh, M, Sumich, A ORCID: https://orcid.org/0000-0003-4333-8442, Singh, B, Merkin, A, Budhraja, S, Goh, W, Lai, EM-K, Williams, M, Tan, S, Lee, J and Kasabov, N, 2023. Investigation of social and cognitive predictors in non-transition ultra-high-risk’ individuals for psychosis using spiking neural networks. Schizophrenia, 9 (1): 10. ISSN 2334-265X

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Official URL: https://doi.org/10.1038/s41537-023-00335-2

Abstract

Finding predictors of social and cognitive impairment in non-transition Ultra-High-Risk individuals (UHR) is critical in prognosis and planning of potential personalised intervention strategies. Social and cognitive functioning observed in youth at UHR for psychosis may be protective against transition to clinically relevant illness. The current study used a computational method known as Spiking Neural Network (SNN) to identify the cognitive and social predictors of transitioning outcome. Participants (90 UHR, 81 Healthy Control (HC)) completed batteries of neuropsychological tests in the domains of verbal memory, working memory, processing speed, attention, executive function along with social skills-based performance at baseline and 4 × 6-month follow-up intervals. The UHR status was recorded as Remitters, Converters or Maintained. SNN were used to model interactions between variables across groups over time and classify UHR status. The performance of SNN was examined relative to other machine learning methods. Higher interaction between social and cognitive variables was seen for the Maintained, than Remitter subgroup. Findings identified the most important cognitive and social variables (particularly verbal memory, processing speed, attention, affect and interpersonal social functioning) that showed discriminative patterns in the SNN models of HC vs UHR subgroups, with accuracies up to 80%; outperforming other machine learning models (56–64% based on 18 months data). This finding is indicative of a promising direction for early detection of social and cognitive impairment in UHR individuals that may not anticipate transition to psychosis and implicate early initiated interventions to stem the impact of clinical symptoms of psychosis.

Item Type:	Journal article
Publication Title:	Schizophrenia
Creators:	Doborjeh, Z., Doborjeh, M., Sumich, A., Singh, B., Merkin, A., Budhraja, S., Goh, W., Lai, E.M.-K., Williams, M., Tan, S., Lee, J. and Kasabov, N.
Publisher:	Springer Science and Business Media LLC
Date:	2023
Volume:	9
Number:	1
ISSN:	2334-265X
Identifiers:	Number Type 10.1038/s41537-023-00335-2 DOI 1733907 Other
Rights:	© The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Divisions:	Schools > School of Social Sciences
Record created by:	Laura Ward
Date Added:	20 Feb 2023 12:26
Last Modified:	20 Feb 2023 12:26
URI:	https://irep.ntu.ac.uk/id/eprint/48364