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Asteal, F, 2011. A study of immune responses to Leishmania mexicana antigens and immunogenicity of L. donovani Centrin-3. PhD, Nottingham Trent University.
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Abstract
Leishmaniasis is a parasitic protozoal disease affecting humans and animals with phlebotomine sand flies as intermediate vectors. The parasite infects phagocytic cells of the mammalian host where they transform from the flagellated promastigote to non-flagellated amastigote phase. There is no effective vaccine in use against this parasite and production relies on finding potent immunogenic antigens with a Th1 bias and long lasting memory response. In this study the immunogenicity of L. mexicana Soluble Leishmania Antigens (SLA) prepared by two different methods (SLA1&2) was investigated by immunisation of Balb/c mice and challenge with live L. mexicana and an in vitro immunological analysis. Immunisation of Balb/c mice with SLA mixed with IFA adjuvant significantly protected against challenge with live L. mexicana parasites.
| Item Type: | Thesis |
|---|---|
| Alternative Title: | A study of immune responses to L. mexicana antigens and immunogenicity of L. donovani Centrin-3 A study of immune responses to L. mexicana antigens and immunogenicity of L. donovani CEN-3 |
| Description: | A thesis submitted in partial fulfilment of the requirements of Nottingham Trent University for transfer of registration from Master of Philosophy to Doctor of Philosophy |
| Creators: | Asteal, F. |
| Date: | 2011 |
| Divisions: | Schools > School of Science and Technology |
| Record created by: | EPrints Services |
| Date Added: | 09 Oct 2015 09:33 |
| Last Modified: | 09 Oct 2015 09:33 |
| URI: | https://irep.ntu.ac.uk/id/eprint/53 |
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