Items where Author is "Vadakekolathu, J"

Journal article

HATZIAPOSTOLOU, M., KOUTSIOUMPA, M., ZAITOUN, A.M., POLYTARCHOU, C., EDDERKAOUI, M., MAHURKAR-JOSHI, S., VADAKEKOLATHU, J., D'ANDREA, D., LAY, A.R., CHRISTODOULOU, N., PHAM, T., YAU, T.-O., VORVIS, C., CHATTERJI, S., PANDOL, S.J., POULTSIDES, G.A., DAWSON, D.W., LOBO, D.N. and ILIOPOULOS, D., 2024. Promoter methylation leads to Hepatocyte Nuclear Factor 4A loss and pancreatic cancer aggressiveness. Gastro Hep Advances, 3 (5), pp. 687-702. ISSN 2772-5723

OCADLIKOVA, D., LUSSANA, F., FRACCHIOLLA, N., BONIFACIO, M., SANTORO, L., DELIA, M., CHIARETTI, S., PASCIOLLA, C., CIGNETTI, A., FORGHIERI, F., GRIMALDI, F., CORRADI, G., ZANNONI, L., DE PROPRIS, S., BORLERI, G.M., TANASI, I., VADAKEKOLATHU, J., RUTELLA, S., GUARINI, A.R., FOÀ, R., CURTI, A. and THE CAMPUS ALL, 2023. Blinatumomab differentially modulates peripheral blood and bone marrow immune cell repertoire: a Campus ALL study. British Journal of Haematology. ISSN 0007-1048

VADAKEKOLATHU, J. and RUTELLA, S., 2023. Escape from T-cell targeting immunotherapies in acute myeloid leukemia. Blood. ISSN 0006-4971

TORABI, F., VADAKEKOLATHU, J., WYATT, R., LEETE, P., TOMBS, M.A., RICHARDSON, C.C., BOOCOCK, D.J., TURNER, M.D., MORGAN, N.G., RICHARDSON, S.J. and CHRISTIE, M.R., 2023. Differential expression of genes controlling lymphocyte differentiation and migration in two distinct endotypes of type 1 diabetes. Diabetic Medicine. ISSN 0742-3071

ATOBATELE, A.G., TONOLI, E., VADAKEKOLATHU, J., SAVOCA, M.P., BARR, M., KATARIA, Y., ROSSANESE, M., BURHAN, I., MCARDLE, S., CACCAMO, D. and VERDERIO, E.A.M., 2023. Canonical and truncated transglutaminase-2 regulate mucin-1 expression and androgen independency in prostate cancer cell lines. Cell Death and Disease, 14 (5): 317. ISSN 2041-4889

RUTELLA, S., VADAKEKOLATHU, J., MAZZIOTTA, F., REEDER, S., YAU, T.-O., MUKHOPADHYAY, R., DICKINS, B., ALTMANN, H., KRAMER, M., KNAUS, H.A., BLAZAR, B.R., RADOJCIC, V., ZEIDNER, J.F., ARRUDA, A., WANG, B., ABBAS, H.A., MINDEN, M.D., TASIAN, S.K., BORNHÄUSER, M., GOJO, I. and LUZNIK, L., 2022. Signatures of immune dysfunction predict outcomes and define checkpoint blockade-unresponsive microenvironments in acute myeloid leukemia. Journal of Clinical Investigation. ISSN 0021-9738

CORRADI, G., BASSANI, B., SIMONETTI, G., SANGALETTI, S., VADAKEKOLATHU, J., FONTANA, M.C., PAZZAGLIA, M., GULINO, A., TRIPODO, C., CRISTIANO, G., BANDINI, L., OTTAVIANI, E., OCADLIKOVA, D., PICCIOLI, M., MARTINELLI, G., COLOMBO, M.P., RUTELLA, S., CAVO, M., CICIARELLO, M. and CURTI, A., 2022. Release of IFNγ by acute myeloid leukemia cells remodels bone marrow immune microenvironment by inducing regulatory T cells. Clinical Cancer Research, OF1-OF15. ISSN 1078-0432

LE VU, P., VADAKEKOLATHU, J., IDRI, S., NICHOLLS, H., CAVAIGNAC, M., REEDER, S., KHAN, M.A., CHRISTENSEN, D., POCKLEY, A.G. and MCARDLE, S.E., 2022. A mutated prostatic acid phosphatase (PAP) peptide-based vaccine induces PAP-specific CD8+ T cells with ex vivo cytotoxic capacities in HHDII/DR1 transgenic mice. Cancers, 14 (8): 1970. ISSN 2072-6694

HOWARD, F.H.N., AL‐JANABI, H., PATEL, P., COX, K., SMITH, E., VADAKEKOLATHU, J., POCKLEY, A.G., CONNER, J., NOHL, J.F., ALLWOOD, D.A., COLLADO‐ROJAS, C., KENNERLEY, A., STANILAND, S. and MUTHANA, M., 2022. Nanobugs as drugs: bacterial derived nanomagnets enhance tumor targeting and oncolytic activity of HSV‐1 virus. Small: 2104763. ISSN 1613-6810

FERRI, C., DI BIASE, A., BOCCHETTI, M., ZAPPAVIGNA, S., WAGNER, S., LE VU, P., LUCE, A., COSSU, A.M., VADAKEKOLATHU, J., MILES, A., BOOCOCK, D.J., ROBINSON, A., SCHWERDTFEGER, M., TIRINO, V., PAPACCIO, F., CARAGLIA, M., REGAD, T. and DESIDERIO, V., 2022. MiR-423-5p prevents MALAT1-mediated proliferation and metastasis in prostate cancer. Journal of Experimental and Clinical Cancer Research, 41 (1): 40. ISSN 1756-9966

YAU, T.O., VADAKEKOLATHU, J., FOULDS, G.A., DU, G., DICKINS, B., POLYTARCHOU, C. and RUTELLA, S., 2021. Hyperactive neutrophil chemotaxis contributes to anti‐TNFα treatment resistance in inflammatory bowel disease. Journal of Gastroenterology and Hepatology. ISSN 0815-9319

RAGAINI, S., WAGNER, S., MARCONI, G., PARISI, S., SARTOR, C., NANNI, J., CRISTIANO, G., TALAMI, A., OLIVI, M., OCADLIKOVA, D., CICIARELLO, M., CORRADI, G., OTTAVIANI, E., PAPAYANNIDIS, C., PAOLINI, S., VADAKEKOLATHU, J., CAVO, M., RUTELLA, S. and CURTI, A., 2021. An IDO1-related immune gene signature predicts overall survival in acute myeloid leukemia. Blood Advances. ISSN 2473-9529

TULOTTA, C., LEFLEY, D.V., MOORE, C.K., AMARIUTEI, A.E., SPICER-HADLINGTON, A.R., QUAYLE, L.A., HUGHES, R.O., AHMED, K., COOKSON, V., EVANS, C.A., VADAKEKOLATHU, J., HEATH, P., FRANCIS, S., PINTEAUX, E., POCKLEY, A.G. and OTTEWELL, P.D., 2021. IL-1B drives opposing responses in primary tumours and bone metastases; harnessing combination therapies to improve outcome in breast cancer. npj Breast Cancer, 7: 95. ISSN 2374-4677

ALMSHAYAKHCHI, R., NAGARAJAN, D., VADAKEKOLATHU, J., GUINN, B.-A., REEDER, S., BRENTVILLE, V., METHERINGHAM, R., POCKLEY, A.G., DURRANT, L. and MCARDLE, S., 2021. A novel HAGE/WT1-ImmunoBody® vaccine combination enhances anti-tumour responses when compared to either vaccine alone. Frontiers in Oncology, 11: 636977.

ZHOU, Q., VADAKEKOLATHU, J., WATAD, A., SHARIF, K., RUSSELL, T., ROWE, H., KHAN, A., MILLNER, P.A., LOUGHENBURY, P., RAO, A., DUNSMUIR, R., TIMOTHY, J., DAMIANI, G., PIGATTO, P.D.M., MALAGOLI, P., BANFI, G., EL-SHERBINY, Y.M., BRIDGEWOOD, C. and MCGONAGLE, D., 2021. SARS-CoV-2 infection induces psoriatic arthritis flares and enthesis resident plasmacytoid dendritic cell type-1 interferon inhibition by JAK antagonism offer novel spondyloarthritis pathogenesis insights. Frontiers in Immunology, 12: 635018. ISSN 1664-3224

KWAN, A., WINDER, N.J., ATKINSON, E., AL-JANABI, H.H., ALLEN, R.J., HUGHES, R., MOAMIN, M.R., LOUIE, R., EVANS, D., HUTCHINSON, M., CAPPER, D.T., COX, K., HANDLEY, J.T., WILSHAW, A., KIM, T., TAZZYMAN, S.J., SRIVASTAVA, S.K., OTTEWELL, P.D., VADAKEKOLATHU, J., POCKLEY, A.G., LEWIS, C.E., BROWN, J.E., DANSON, S., CONNER, J. and MUTHANA, M., 2020. Macrophages mediate the anti-tumor effects of the oncolytic virus HSV1716 in mammary tumors. Molecular Cancer Therapeutics. ISSN 1535-7163

VADAKEKOLATHU, J., LAI, C., REEDER, S., CHURCH, S.E., HOOD, T., LOURDUSAMY, A., RETTIG, M.P., ALDOSS, I., ADVANI, A.S., GODWIN, J., WIEDUWILT, M.J., ARELLANO, M., MUTH, J., YAU, T.O., RAVANDI, F., SWEET, K., ALTMANN, H., FOULDS, G.A., STÖLZEL, F., MIDDEKE, J.M., CICIARELLO, M., CURTI, A., VALK, P.J.M., LÖWENBERG, B., GOJO, I., BORNHÄUSER, M., DIPERSIO, J.F., DAVIDSON-MONCADA, J.K. and RUTELLA, S., 2020. TP53 abnormalities correlate with immune infiltration and associate with response to flotetuzumab immunotherapy in AML. Blood Advances, 4 (20), pp. 5011-5024. ISSN 2473-9529

UY, G.L., ALDOSS, I., FOSTER, M.C., SAYRE, P.H., WIEDUWILT, M.J., ADVANI, A.S., GODWIN, J.E., ARELLANO, M.L., SWEET, K., EMADI, A., RAVANDI, F., ERBA, H.P., BYRNE, M., MICHAELIS, L.C., TOPP, M.S., VEY, N., CICERI, F., CARRABBA, M.G., PAOLINI, S., HULS, G., JONGEN-LAVRENCIC, M., WERMKE, M., CHEVALLIER, P., GYAN, E., RÉCHER, C., STIFF, P., PETTIT, K., LÖWENBERG, B., CHURCH, S., ANDERSON, E.K., VADAKEKOLATHU, J., SANTAGUIDA, M.T., RETTIG, M.P., MUTH, J., CURTIS, T., FEHR, E., GUO, K., ZHAO, J., BAKKACHA, O., JACOBS, K., TRAN, K., KAMINKER, P., KOSTOVA, M., BONVINI, E., WALTER, R.B., DAVIDSON-MONCADA, J.K., RUTELLA, S. and DIPERSIO, J.F., 2020. Flotetuzumab as salvage immunotherapy for refractory acute myeloid leukemia. Blood. ISSN 0006-4971

ZHOU, Q., VADAKEKOLATHU, J., SHARIF, K., RUSSELL, T., ROWE, H., MILLNER, P., LOUGHENBURY, P., RAO, A.S., DUNSMUIR, R., BRIDGEWOOD, C., EL-SHERBINY, Y. and MCGONAGLE, D., 2020. THU0028 an explantion for how viral infection may trigger spondyloarthropathy based on TLR9 driven TNF responses from entheseal derived plasmacytoid dendritic cells. Annals of the Rheumatic Diseases, 79, pp. 227-228. ISSN 0003-4967

CICIARELLO, M., CORRADI, G., SANGALETTI, S., BASSANI, B., SIMONETTI, G., VADAKEKOLATHU, J., MARCONI, G., MARTINELLI, G., COLOMBO, M.P., RUTELLA, S., CAVO, M. and CURTI, A., 2019. Interferon-γ-dependent inflammatory signature in acute myeloid leukemia cells Is able to shape stromal and immune bone marrow microenvironment. Blood, 134 (Supp 1), p. 1212. ISSN 0006-4971

PARK, H., URONIS, H., KANG, Y., NG, M.C.H., ENZINGER, P., LEE, K.W., RUTELLA, S., CHURCH, S.E., NORDSTROM, J., KNUTSON, K., ERSKINE, C., WU, T., YEN, J., FRANOVIC, A., MUTH, J., ROSALES, M., VADAKEKOLATHU, J., DAVIDSON-MONCADA, J., BANG, Y. and CATENACCI, D.V., 2019. Determinants of response of HER2+ gastric cancer (GC) vs gastroesophageal junction adenocarcinoma (GEJ) to margetuximab (M) plus pembrolizumab (P) post trastuzumab (T). Annals of Oncology, 30 (Supp5), v485. ISSN 0923-7534

RUTELLA, S., CHURCH, S.E., VADAKEKOLATHU, J., REEDER, S., SULLIVAN, A.H., WARREN, S., BAUGHMAN, J., MUTH, J., PARK, H., URONIS, H., KANG, Y., NG, M.C.H., ENZINGER, P., LEE, K.W., HUBER, K., WYNTER-HORTON, A., LI, D., BANG, Y., DAVIDSON-MONCADA, J. and CATENACCI, D.V., 2019. Evaluation of tumour microenvironment identifies immune correlates of response to combination immunotherapy with margetuximab (M) and pembrolizumab (P) in HER2+ gastroesophageal adenocarcinoma (GEA). Annals of Oncology, 30 (Supp5), v38-v39. ISSN 0923-7534

AL-JUBOORI, S.I.K., VADAKEKOLATHU, J., IDRI, S., WAGNER, S., ZAFEIRIS, D., PEARSON, J.R.D., ALMSHAYAKHCHI, R., CARAGLIA, M., DESIDERIO, V., MILES, A.K., BOOCOCK, D.J., BALL, G.R. and REGAD, T., 2019. PYK2 promotes HER2-positive breast cancer invasion. Journal of Experimental & Clinical Cancer Research, 38: 210. ISSN 1756-9966

WAGNER, S., VADAKEKOLATHU, J., TASIAN, S.K., ALTMANN, H., BORNHÄUSER, M., POCKLEY, A.G., BALL, G.R. and RUTELLA, S., 2019. A parsimonious 3-gene signature predicts clinical outcomes in an acute myeloid leukemia multicohort study. Blood Advances, 3 (8), pp. 1330-1346. ISSN 2473-9529

RUTELLA, S., CHURCH, S.E., VADAKEKOLATHU, J., VIBOCH, E., SULLIVAN, A.H., HOOD, T., WARREN, S.E., CESANO, A., LA MOTTE-MOHS, R., MUTH, J., LELIÈVRE, H., LOWENBERG, B., DIPERSIO, J.F. and DAVIDSON-MONCADA, J.K., 2018. Adaptive immune gene signatures correlate with response to flotetuzumab, a CD123 × CD3 bispecific Dart® molecule, in patients with relapsed/refractory acute myeloid leukemia. Blood, 132 (S1): 444. ISSN 0006-4971

UY, G.L., RETTIG, M.P., VEY, N., GODWIN, J., FOSTER, M.C., RIZZIERI, D.A., ARELLANO, M.L., TOPP, M.S., HULS, G., JONGEN-LAVRENCIC, M., MARTINELLI, G., PAOLINI, S., CICERI, F., CARRABBA, M.G., SWEET, K.L., RAVANDI, F., CHURCH, S.E., VADAKEKOLATHU, J., RUTELLA, S., SUN, J., YANG, K., BAUGHMAN, J., CURTIS, T., TIMMENY, E., CALI, K., TRAN, K., MUTH, J., LA MOTTE-MOHS, R., POIROT, C., PALLIS, A., CESANO, A., BONVINI, E., WIGGINGTON, J., LOWENBERG, B., DAVIDSON-MONCADA, J.K. and DIPERSIO, J.F., 2018. Phase 1 cohort expansion of flotetuzumab, a CD123×CD3 bispecific Dart® protein in patients with relapsed/refractory acute myeloid leukemia (AML). Blood, 132 (S1): 764. ISSN 0006-4971

FOULDS, G.A., VADAKEKOLATHU, J., ABDEL-FATAH, T.M.A., NAGARAJAN, D., REEDER, S., JOHNSON, C., HOOD, S., MOSELEY, P.M., CHAN, S.Y.T., POCKLEY, A.G., RUTELLA, S. and MCARDLE, S.E.B., 2018. Immune-phenotyping and transcriptomic profiling of peripheral blood mononuclear cells from patients with breast cancer: identification of a 3 gene signature which predicts relapse of triple negative breast cancer. Frontiers in Immunology, 9: 2028. ISSN 1664-3224

VADAKEKOLATHU, J., FOULDS, G.A., PATEL, T., REEDER, S., POCKLEY, A.G., TASIAN, S.K. and RUTELLA, S., 2018. Immune gene expression profiling identifies predictors of relapse in childhood acute myeloid leukemia. Cancer Immunology Research, 6 (9 Supp): B62. ISSN 2326-6066

VADAKEKOLATHU, J., AL-JUBOORI, S.I.K., JOHNSON, C., SCHNEIDER, A., BUCZEK, M.E., DI BIASE, A., POCKLEY, A.G., BALL, G.R., POWE, D.G. and REGAD, T., 2018. MTSS1 and SCAMP1 cooperate to prevent invasion in breast cancer. Cell Death & Disease, 9: 344. ISSN 2041-4889

RUTELLA, S., VADAKEKOLATHU, J., ALTMANN, H., PATEL, T., REEDER, S., LIANG, Y., SCHMITZ, M., HOOD, T., DANAHER, P., WARREN, S., CESANO, A., BEECHEM, J.M., POCKLEY, A.G., TASIAN, S.K. and BORNHÄUSER, M., 2018. Capturing the complexity of the immune microenvironment of acute myeloid leukemia with 3D biology technology. Journal of Clinical Oncology, 36 (5 supp), p. 50. ISSN 0732-183X

BALAHMAR, R.M., BOOCOCK, D.J., COVENEY, C., RAY, S., VADAKEKOLATHU, J., REGAD, T., ALI, S. and SIVASUBRAMANIAM, S., 2018. Identification and characterisation of NANOG+/OCT-4high/SOX2+ doxorubicin-resistant stem-like cells from transformed trophoblastic cell lines. Oncotarget. ISSN 1949-2553

VADAKEKOLATHU, J., PATEL, T., REEDER, S., SCHAARSCHMIDT, H., SCHMITZ, M., BORNHÄUSER, M., WARREN, S.E., HOOD, T., DANAHER, P., CESANO, A., BEECHEM, J.M., POCKLEY, A.G., TASIAN, S.K. and RUTELLA, S., 2017. Immune gene expression profiling in children and adults with acute myeloid leukemia identifies distinct phenotypic patterns. Blood, 130 (Supp 1), 3942A. ISSN 0006-4971

VADAKEKOLATHU, J., MEREDITH, R., ROSS, P.M., WAGNER, S., REEDER, S., DEMIRKAN, G., KUHAR, J.R., BALL, G.R., POCKLEY, A.G. and RUTELLA, S., 2017. Interferon-γ induces distinct mRNA and protein profiles in acute and chronic myeloid leukemia. Blood, 130 (Supp 1), 3945A. ISSN 0006-4971

HARNER-FOREMAN, N., VADAKEKOLATHU, J., LAVERSIN, S.A., MATHIEU, M.G., REEDER, S., POCKLEY, A.G., REES, R.C. and BOOCOCK, D.J., 2017. A novel spontaneous model of epithelial-mesenchymal transition (EMT) using a primary prostate cancer derived cell line demonstrating distinct stem-like characteristics. Scientific Reports, 7, p. 40633. ISSN 2045-2322

ZAFEIRIS, D., VADAKEKOLATHU, J., WAGNER, S., POCKLEY, A.G., BALL, G.R. and RUTELLA, S., 2017. Discovery and application of immune biomarkers for hematological malignancies. Expert Review of Molecular Diagnostics, 17 (11), pp. 983-1000. ISSN 1473-7159

VADAKEKOLATHU, J. and RUTELLA, S., 2017. T-Cell manipulation strategies to prevent graft-versus-host disease in haploidentical stem cell transplantation. Biomedicines, 5 (2), p. 33. ISSN 2227-9059

SAIF, J.M.S., VADAKEKOLATHU, J., RANE, S.S., MCDONALD, D., AHMAD, M., MATHIEU, M., POCKLEY, A.G., DURRANT, L., METHERINGHAM, R., REES, R.C. and MCARDLE, S.E.B., 2014. Novel prostate acid phosphatase-based peptide vaccination strategy induces antigen-specific T-cell responses and limits tumour growth in mice. European Journal of Immunology, 44 (4), pp. 994-1004. ISSN 0014-2980

Chapter in book

VADAKEKOLATHU, J., MILES, A.K., BOOCOCK, D.J. and MCARDLE, S.E.B., 2014. Identification of tumor antigens for clinical evaluation. In: Tumor immunology and immunotherapy. Oxford: Oxford University Press, pp. 127-129. ISBN 9780199676866

Thesis

VADAKEKOLATHU, J., 2013. Characterisation of high and low avidity peptide specific CD8+ T cells using immunologic, transcriptomic and proteomic tools. PhD, Nottingham Trent University.